diff --git a/zerver/openapi/markdown_extension.py b/zerver/openapi/markdown_extension.py
index 4c191134ed..c605dba544 100644
--- a/zerver/openapi/markdown_extension.py
+++ b/zerver/openapi/markdown_extension.py
@@ -24,6 +24,7 @@ from zerver.openapi.openapi import (
     get_curl_include_exclude,
     get_openapi_description,
     get_openapi_summary,
+    get_responses_description,
     openapi_spec,
 )
 
@@ -34,6 +35,7 @@ PYTHON_EXAMPLE_REGEX = re.compile(r"\# \{code_example\|\s*(.+?)\s*\}")
 JS_EXAMPLE_REGEX = re.compile(r"\/\/ \{code_example\|\s*(.+?)\s*\}")
 MACRO_REGEXP_DESC = re.compile(r"\{generate_api_description(\(\s*(.+?)\s*\))}")
 MACRO_REGEXP_TITLE = re.compile(r"\{generate_api_title(\(\s*(.+?)\s*\))}")
+MACRO_REGEXP_RESPONSE_DESC = re.compile(r"\{generate_response_description(\(\s*(.+?)\s*\))}")
 
 PYTHON_CLIENT_CONFIG = """
 #!/usr/bin/env python3
@@ -407,6 +409,11 @@ class APIMarkdownExtension(Extension):
         md.preprocessors.register(
             APITitlePreprocessor(md, self.getConfigs()), "generate_api_title", 531
         )
+        md.preprocessors.register(
+            ResponseDescriptionPreprocessor(md, self.getConfigs()),
+            "generate_response_description",
+            531,
+        )
 
 
 class APICodeExamplesPreprocessor(Preprocessor):
@@ -541,5 +548,42 @@ class APITitlePreprocessor(Preprocessor):
         return title
 
 
+class ResponseDescriptionPreprocessor(Preprocessor):
+    def __init__(self, md: markdown.Markdown, config: Mapping[str, Any]) -> None:
+        super().__init__(md)
+        self.api_url = config["api_url"]
+
+    def run(self, lines: List[str]) -> List[str]:
+        done = False
+        while not done:
+            for line in lines:
+                loc = lines.index(line)
+                match = MACRO_REGEXP_RESPONSE_DESC.search(line)
+
+                if match:
+                    function = match.group(2)
+                    text = self.render_responses_description(function)
+                    # The line that contains the directive to include the macro
+                    # may be preceded or followed by text or tags, in that case
+                    # we need to make sure that any preceding or following text
+                    # stays the same.
+                    line_split = MACRO_REGEXP_RESPONSE_DESC.split(line, maxsplit=0)
+                    preceding = line_split[0]
+                    following = line_split[-1]
+                    text = [preceding, *text, following]
+                    lines = lines[:loc] + text + lines[loc + 1 :]
+                    break
+            else:
+                done = True
+        return lines
+
+    def render_responses_description(self, function: str) -> List[str]:
+        description: List[str] = []
+        path, method = function.rsplit(":", 1)
+        raw_description = get_responses_description(path, method)
+        description.extend(raw_description.splitlines())
+        return description
+
+
 def makeExtension(*args: Any, **kwargs: str) -> APIMarkdownExtension:
     return APIMarkdownExtension(*args, **kwargs)
diff --git a/zerver/openapi/openapi.py b/zerver/openapi/openapi.py
index 62e3f1e3bd..611d9b1132 100644
--- a/zerver/openapi/openapi.py
+++ b/zerver/openapi/openapi.py
@@ -233,6 +233,13 @@ def check_requires_administrator(endpoint: str, method: str) -> bool:
     )
 
 
+def get_responses_description(endpoint: str, method: str) -> str:
+    """Fetch responses description of an endpoint."""
+    return openapi_spec.openapi()["paths"][endpoint][method.lower()].get(
+        "x-response-description", ""
+    )
+
+
 def generate_openapi_fixture(endpoint: str, method: str, status_code: str = "200") -> List[str]:
     """Generate fixture to be rendered"""
     fixture = []